At 15.8% CAGR, the North America T Cell Therapy Market is projected to be worth US$ 5,329.75 million by 2030, says Business Market Insights

According to Business Market Insights’ research, the North America T cell therapy market was valued at US$ 1,645.52 million in 2022 and is expected to reach US$ 5,329.75 million by 2030, registering a CAGR of 15.8% from 2022 to 2030. Rising number of CAR T-Cell therapies in clinical trials and growing burden of cancer are among the critical factors attributed to the North America T cell therapy market expansion.             

The current landscape for CAR T-cell therapies across the globe is promising, with multiple drug approvals, a rich pipeline, and many ongoing clinical trials. Pipelines of CAR T-cell therapies are in various stages of clinical development; major pharmaceutical companies are working to advance the pipeline space and future growth potential of the CAR T-cell therapy competitive domain. In November 2022, Peter MacCallum Cancer Centre and Cartherics Pty Ltd entered into a Collaborative Development Program Agreement (CDPA) to develop Cartherics’ proprietary autologous CAR T cell therapy (CTH-001) for treating cutaneous T-cell lymphoma (CTCL). The key aspects of the collaborative research are setting up clinical-scale manufacturing of CTH-001 and conducting a Phase I clinical trial. It will initially enroll six patients with refractory CTCL. JW Therapeutics drug JWCAR029 is a CAR T cell product that targets CD19 and is intended to treat advanced lymphoma and leukemia. The molecule is currently in Phase II of development. JWCAR029 is initially being investigated for treating B-cell malignancies, focusing on relapsed and refractory DLBCL. Gilead Sciences drug KTE-X19 is an autologous CD19 CAR T-cell therapy under investigation. The drug is manufactured using the XLP process, including T-cell selection and lymphocyte enrichment. Lymphocyte enrichment is required in certain B-cell malignancies for which KTE-X19 is being studied. KTE-X19 is currently in Phase II clinical trials for the treatment of both adult and pediatric acute lymphocytic leukemia. The FDA has approved Brexucabtagene autoleucel (formerly KTE-X19; Tecartus) for treating adult patients with relapsed or refractory mantle cell lymphoma (MCL). ZUMA-3 is a Phase 1/2 study evaluating KTE-X19, an autologous anti-CD19 CAR T-cell therapy, in adult relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). Descartes-11, a mRNA CAR T-cell therapy, has moved into a Phase II clinical trial for newly diagnosed, high-risk multiple myeloma (MM) patients. Descartes-11 expresses CAR T-cell molecules transiently and avoids some characteristic toxicities of these therapeutic agents. A Phase I study (NCT03994705) of 18 patients has already been undertaken, and results showed no evidence of cytokine release syndrome or neurotoxicity—adverse events commonly associated with CAR T-cell treatment. Thus, the pipelines above for CAR T-cell therapies are emerging as a new trend in the North America T-cell therapy market.

On the contrary, side-effects of CAR T-cell therapy hampers on the growth of North America T cell therapy market. 

Based on modality, the North America T cell therapy market is bifurcated into research and commercialized. The commercialized segment held 90.1% market share in 2022, amassing US$ 1,482.36 million. It is projected to garner US$ 4,908.11 million by 2030 to expand at 16.1% CAGR during 2022–2030.

Based on therapy type, the North America T cell therapy market is divided into CAR T-cell therapy and T-cell Receptor (TCR)-based. The CAR T-cell therapy segment held 93.5% share of North America T cell therapy market in 2022, amassing US$ 1,538.47 million. It is projected to garner US$ 5,025.67 million by 2030 to expand at 15.9% CAGR during 2022–2030.

Based on indication, the North America T cell therapy market is bifurcated into hematologic malignancies and solid tumors. The hematologic malignancies segment held 93.5% share of North America T cell therapy market in 2022, amassing US$ 1,538.47 million. It is projected to garner US$ 5,025.67 million by 2030 to expand at 15.9% CAGR during 2022–2030.

Based on country, the North America T cell therapy market has been categorized into the US, Canada, and Mexico. Our regional analysis states that the US captured 83.8% share of North America T cell therapy market in 2022. It was assessed at US$ 1,378.27 million in 2022 and is likely to hit US$ 4,582.90 million by 2030, exhibiting a CAGR of 16.2% during 2022–2030.            

Key players operating in the North America T cell therapy market are Bluebird Bio Inc, Bristol-Myers Squibb Co, Cartesian Therapeutics Inc, Gilead Sciences Inc, Innovent Biologics Inc, Janssen Global Services LLC, and Novartis AG, among others.

• May 2022: Novartis declared that the US Food and Drug Administration (FDA) has approved Kymriah (Tisagenlecleucel) for the treatment of adult patients with relapsed or refractory (r/r) follicular lymphoma (FL) after two or more lines of systemic therapy. Kymriah is now FDA approved in three indications and remains the only CAR-T cell therapy approved in both adult and pediatric settings.

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